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RCT
ACE Report #10280
Ace Report Cover Arthroplasty

Early analgesia improved with two-dose perioperative IV dexamethasone in total knee arthroplasty


Study Type:Randomized Trial
OE Level Evidence:2
Journal Level of Evidence:1

Two doses of low-dose perioperative dexamethasone improve the clinical outcome after total knee arthroplasty: a randomized controlled study

Knee Surg Sports Traumatol Arthrosc. 2018 May;26(5):1549-1556

Contributing Authors: J Ma FX Pei Q Huang ZY Huang B Xu SY Zhang

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Synopsis

108 patients scheduled for total knee arthroplasty were randomized to two perioperative doses of either intravenous dexamethasone 10mg or intravenous saline. Patients were followed up over the first three days postoperatively. Pain scores at rest and on movement were significantly lower in the IV dexamethasone group compared to the control group at 24 hours, but not 48 or 72 hours. Additionally, r...

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