Larger BMD gains in osteoporosis patients transitioning to denosumab versus other active controls

How to Cite

OrthoEvidence. Larger BMD gains in osteoporosis patients transitioning to denosumab versus other active controls. ACE Report. 2019;8(1):24. Available from: https://myorthoevidene.com/AceReport/Report/10252

Study Type:Meta-analysis/Systematic Review

OE Level Evidence:1

Journal Level of Evidence:N/A

Safety and efficacy of denosumab in osteoporotic patients previously treated with other medications: a systematic review and metaanalysis

Expert Opin Drug Saf. 2018 Apr;17(4):413-428

Contributing Authors: EI Kenanidis ME Potoupnis E Tsiridis A Fontalis E Prousali

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Synopsis

6 randomized controlled trials were included in this meta-analysis which aimed to compare increase in bone mineral density measurements between denosumab and other active anti-osteoporosis medications among postmenopausal women with osteoporosis and who had previously been administered anti-osteoporosis therapy. In pooled analyses, percent increase in bone mineral density measured at the total hip...