Larger BMD gains in osteoporosis patients transitioning to denosumab versus other active controls

Study Type:Meta-analysis/Systematic Review

OE Level Evidence:1

Journal Level of Evidence:N/A

Safety and efficacy of denosumab in osteoporotic patients previously treated with other medications: a systematic review and metaanalysis

Expert Opin Drug Saf. 2018 Apr;17(4):413-428

Contributing Authors: EI Kenanidis ME Potoupnis E Tsiridis A Fontalis E Prousali

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Synopsis

6 randomized controlled trials were included in this meta-analysis which aimed to compare increase in bone mineral density measurements between denosumab and other active anti-osteoporosis medications among postmenopausal women with osteoporosis and who had previously been administered anti-osteoporosis therapy. In pooled analyses, percent increase in bone mineral density measured at the total hip...