PRP Combined with Hyaluronic Acid vs. Autologous Microfragmented Adipose Tissue for Early Knee OA
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A Prospective Study Comparing Leukocyte-Poor Platelet-Rich Plasma Combined with Hyaluronic Acid and Autologous Microfragmented Adipose Tissue in Patients with Early Knee Osteoarthritis.
Stem Cells Dev. 2021 Jul 1;30(13): 651-659.Exclusive Author Interview
Fifty patients (80 knees) were randomized to receive a single injection of autologous microfragmented adipose tissue (AMAT; n=25, 40 knees) or 3 monthly injections of leukocyte-poor platelet-rich plasma (PRP) plus hyaluronic acid (HA) (n=25, 40 knees). The primary outcomes of interest were pain, symptoms and activity level. Outcomes were assessed at 6 and 12 months follow up. Results revealed no significant differences between the two groups in Visual Analog Scale (VAS) pain scores, Marx scores, or the sub-scores of Knee Injury and Osteoarthritis Outcome Score (KOOS) for pain, activities of daily living, sport, and quality of life at both 6 and 12 months follow up. However, KOOS symptoms scores at 6 months, as well as Tegner scores as 6 and 12 months, were significantly in favour of the AMAT group compared to the PRP+HA group.
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