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Micro-Fragmented Adipose Tissue vs Saline for Knee Osteoarthritis
November 2025
Micro-Fragmented Adipose Tissue vs Saline for Knee Osteoarthritis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Treatment of knee osteoarthritis with a single injection of autologous micro-fragmented adipose tissue is not superior to a placebo saline injection: a blinded randomised controlled trial with 2-year follow-up.
Br J Sports Med . 2025 Aug 26;59(17):1219-1227.Synopsis
One hundred twenty patients with symptomatic tibiofemoral knee osteoarthritis (Kellgren–Lawrence grade 2–3) were randomised to receive a single intra-articular injection of autologous micro-fragmented adipose tissue (n=60) or placebo isotonic saline (n=60) following abdominal liposuction. The primary outcome of interest was KOOS4 at 6 months. Secondary outcomes included KOOS subscales (Pain, Sympt...
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