Perioperative Teriparatide vs Denosumab for Junctional Complications
Perioperative Teriparatide vs Denosumab for Junctional Complications
Perioperative teriparatide for preventing proximal junctional kyphosis and failure in patients with osteoporosis after adult thoracolumbar spinal deformity surgery: a prospective randomized controlled trial.
Osteoporos Int . 2025 May;36(5):833-843.Synopsis
Sixty-four postmenopausal women with osteoporosis undergoing adult spinal deformity surgery were randomized to receive perioperative teriparatide (n=32) or denosumab (n=32). The primary outcome of interest was the incidence of proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) within 12 months after surgery. Secondary outcomes of interest included changes in hip bone mineral ...
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