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Subfascial Analgesic Cocktail at Closure for AIS Posterior Fusion: Double-Blind RCT
November 2025
Subfascial Analgesic Cocktail at Closure for AIS Posterior Fusion: Double-Blind RCT
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effect of a Surgeon-Directed Cocktail of Ropivacaine, Methylprednisolone, and Ketoprofen on Postoperative Pain and Ambulation in Adolescent Idiopathic Scoliosis Surgery: A Double-Blind Randomized Controlled Trial.
Spine (Phila Pa 1976) . 2025 Jul 1;50(13):902-908.Synopsis
Forty-four adolescents with idiopathic scoliosis (AIS) were randomized to receive a surgeon-directed subfascial cocktail of ropivacaine 0.75% (20 mL), methylprednisolone 40 mg, and ketoprofen 50 mg (n=23) or saline (40 mL) (n=21) at wound closure during posterior fusion. The primary outcome was postoperative pain on an NRS (0–10) at 1 h, 6 h, and daily to postoperative day (POD) 3; secondary outco...
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