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Vol:10 Issue:3 Number:2 ISSN#:2564-2537
ACE Report #13120
Ace Report Cover Arthroplasty

Ramelteon Ineffective in Preventing Post-Op Delirium in Patients Undergoing Joint Replacement

How to Cite

OrthoEvidence. Ramelteon Ineffective in Preventing Post-Op Delirium in Patients Undergoing Joint Replacement. ACE Report. 2021;10(3):2. Available from:

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Effects of Ramelteon on the Prevention of Postoperative Delirium in Older Patients Undergoing Orthopedic Surgery: The RECOVER Randomized Controlled Trial

Am J Geriatr Psychiatry. 2021 Jan;29(1):90-100.

Contributing Authors: ES Oh JM Leoutsakos PB Rosenberg AM Pletnikova HS Khanuja RS Sterling JK Oni FE Sieber NS Fedarko N Akhlaghi KJ Neufeld

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Eighty patients scheduled for a hip or knee replacement surgery were randomized to receive oral ramelteon (n=41) or placebo (n=39) for the prevention of post-operative delirium. The primary outcome of interest was the incidence of delirium during post-operative day 0 and post-operative day 1-2, as measured by the Aldrete score. Secondary outcomes included the Delirium Rating Scale Revised 98 (DRS-...

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