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Ramelteon Ineffective in Preventing Post-Op Delirium in Patients Undergoing Joint Replacement
March 2021
Ramelteon Ineffective in Preventing Post-Op Delirium in Patients Undergoing Joint Replacement
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effects of Ramelteon on the Prevention of Postoperative Delirium in Older Patients Undergoing Orthopedic Surgery: The RECOVER Randomized Controlled Trial
Am J Geriatr Psychiatry. 2021 Jan;29(1):90-100.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Eighty patients scheduled for a hip or knee replacement surgery were randomized to receive oral ramelteon (n=41) or placebo (n=39) for the prevention of post-operative delirium. The primary outcome of interest was the incidence of delirium during post-operative day 0 and post-operative day 1-2, as measured by the Aldrete score. Secondary outcomes included the Delirium Rating Scale Revised 98 (DRS-...
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