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CBD 600mg Normalizes Neuroendocrine and Anxiety Responses to Stress in Patients at Risk of Psychosis

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Ace Report Cover
August 2020

CBD 600mg Normalizes Neuroendocrine and Anxiety Responses to Stress in Patients at Risk of Psychosis

Vol: 9| Issue: 8| Number:3| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis

Psychopharmacology. 2020;237:1121-1130

Contributing Authors:
E Appiah-Kusi N Petros R Wilson M Colizzi MG Bossong L Valmaggia V Mondelli P McGuire S Bhattacharyya

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Synopsis

Thirty-two participants at clinical high risk (CHR) for psychosis were randomized to receive either cannabidiol (CBD) 600 mg/day (CHR-CBD) or placebo (CHR-P) for one week. The CHR participants and 25 healthy controls (HC) then performed a psychosocial stress task. The primary outcome was the neuroendocrine response to stress measured by serum cortisol levels. Other outcomes of interest included su...

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