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Assessing efficacy of allogeneic, bone marrow-derived mesenchymal stem cells in knee OA treatment
May 2019
Assessing efficacy of allogeneic, bone marrow-derived mesenchymal stem cells in knee OA treatment
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:2
Efficacy and safety of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel): preclinical and clinical trial in osteoarthritis of the knee joint
Arthritis Res Ther. 2016 Dec 20;18(1):301.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
60 patients with Kellgren-Lawrence grade II-II knee osteoarthritis were randomized to one of five treatments: bone marrow--derived allogeneic mesenchymal stromal cell injection at either a 25, 50, 75, or 150 million cell dose, or placebo injection. At each dose level, randomization was conducted at a 2:1 ratio of intervention to placebo; therefore a total of 10 patients were administered at each d...
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