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Combined IV-IA TXA further reduces blood loss versus IV TXA alone, but does not reduce transfusion
February 2019
Combined IV-IA TXA further reduces blood loss versus IV TXA alone, but does not reduce transfusion
Study Type:Meta analysis
OE Level Evidence:1
Journal Level of Evidence:N/A
The efficacy and safety of combined administration of intravenous and topical tranexamic acid in primary total knee arthroplasty: a meta-analysis of randomized controlled trials
BMC Musculoskelet Disord. 2018 Sep 7;19(1):321. doi: 10.1186/s12891-018-2181-9Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Six randomized controlled trials were included in this meta-analysis, which sought to compare efficacy and safety measures between combined intravenous and topical tranexamic acid administration and intravenous tranexamic acid administration alone in total knee arthroplasty. Pooled analyses on total blood loss and maximum hemoglobin drop significantly favoured combined IV-IA TXA groups, though no ...
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