Showing 373 - 383 of 383 reports matching: Osteoarthritis
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Synopsis: 146 patients were randomized to evaluate the effect of vitamin D supplementation on the symptoms and structural progression of knee osteoarthritis (OA). Patients with knee OA received either placebo or oral cholecalciferol (2000 IU/d) and were assessed after 2 years. Results revealed that Read More »
Level 1 RCT
Synopsis: 50 patients were randomized to receive either high-porosity trabecular metal (TM) tibial components or low-porosity titanium pegged porous fiber-metal (Ti) components in the treatment of primary osteoarthritis of the knee. This study was performed to compare the stability of these cementless implants. The results indicated Read More »
Author verified Level 2 RCT
Synopsis: 293 patients with symptomatic, early-onset (<5 years) knee osteoarthritis (OA) were randomized to undergo either a structured resistance training (RT), a self-management program (SM), or a combination of both (RT+SM) for a 9 month period. Over 9 months it was found that the patients with early-onset knee OA were able to engage in RT without detraction from overall aerobic moderate and vigorous intensity physical activity. The RT group Read More »
Level 2 RCT
Synopsis: 918 patients (>=40 yr) with osteoarthritis (OA) of the knee and managed with oral NSAIDs or acetaminophen, were randomized to 4 groups of either naproxcinod (750 or 375 mg), naproxen (50 mg) or a placebo. At study conclusion (i.e. 13 weeks), naproxcinod was found to be well-tolerated and did not significantly elevate blood pressure more than naproxen. Naproxcinod's clinical efficacy Read More »
Level 2 RCT
Synopsis: 22 patients with knee osteoarthritis (>6 month duration with the pain intensity (PI) while standing <=5 on a 0-10 numeric rating scale (NRS)) were selected. Patients performed multiple 20-minute treadmill walks on Day 1 and Day 3 at a consistent self-selected pace, predetermined at screening in 3 period cross over study once, each while taking naproxen, combination of tramadol and acetaminophen, or a placebo. Results indicated that, Read More »
Level 1 RCT
Synopsis: 36 patients with tibiofemoral osteoarthritis were randomized into three groups to assess the efficacy and compare transcutaneous electrical nerve stimulation in combination with therapeutic exercise to a placebo and control group. TENS treatment has been proposed to improve muscle activation which could provide benefits for this population which often suffers from quadriceps activation failure. The results from Read More »
Level 2 RCT
Synopsis: 381 patients with knee osteoarthritis (OA) were randomized to receive intra-articular injections with either Synovail (highly purified intra-articular hyaluronic acid) or Synvisc (hylan G-F20) once a week for three weeks. This double blinded randomized trial examined the efficacy and non-inferiority of Synovial treatment in patients with OA of the knee. The results from Read More »
Author verified Level 1 RCT
Synopsis: 282 people, aged 50 years or older, with knee pain on most days for at least a month were randomized to the use of a topical or an oral NSAID for a 24 month period. It was observed that both modes of administration were equally efficacious in pain control according to WOMAC (Western Ontario and McMaster Universities) osteoarthritis index. Furthermore, the topical Read More »
Level 2 RCT
Synopsis: 42 patients with radigographically verified degenerative osteoarthritis (OA) of the knee were randomized to receive either hyaluronan or triamcinolone injection treatment. This study assessed the efficacy of hyaluronan and triamcinolone injections for the treatment of OA, while also comparing outcome measures of these two treatments. The results from Read More »
Level 1 RCT
Synopsis: Forty-two patients with osteoarthritis of the medial compartment of the knee were randomized to receive one of two procedural techniques for valgus high tibial osteotomy (HTO). The first group underwent a medial opening-wedge (OW) technique, while the second group underwent a lateral closing-wedge (CW) technique. The primary outcomes Read More »
Author verified Level 2 RCT
Synopsis: 152 patients with osteoarthritis on a joint replacement waiting list were randomized to a self-management and peer support program, or usual care. The primary outcomes were based on the Health Education Impact Questionnaire (HeiQ), measured over a 6 month period. Results indicated a Read More »
Level 2 RCT