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Denosumab increases bone mineral density in male patients with low BMD

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Ace Report Cover
May 2013

Denosumab increases bone mineral density in male patients with low BMD

Vol: 2| Issue: 4| Number:144| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

A Randomized, Placebo-Controlled Study of the Effects of Denosumab for the Treatment of Men with Low Bone Mineral Density

J Clin Endocrinol Metab. 2012 Sep;97(9):3161-9. doi: 10.1210/jc.2012-1569. Epub 2012 Jun 21

Contributing Authors:
E Orwoll CS Teglbjærg BL Langdahl R Chapurlat E Czerwinski DL Kendler JY Reginster A Kivitz EM Lewiecki PD Miller MA Bolognese MR McClung HG Bone Ö Ljunggren B Abrahamsen U Gruntmanis YC Yang RB Wagman S Siddhanti A Grauer JW Hall Boo

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Synopsis

242 male patients with low bone mineral density were randomized to receive treatment with denosumab or a placebo to determine the effect of denosumab on bone mineral density in the male population. After 1 year of treatment, the denosumab group demonstrated a significantly greater increase in bone mineral density than the control group at the lumbar spine, total hip, femoral neck, trochanter, and ...

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