Showing 1 - 12 of 383 reports matching: Osteoarthritis
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Synopsis: 120 patients scheduled for opening wedge high tibial osteotomy were randomized to preoperative planning and intraoperative correction via either the gap measurement method or using computer navigation. The purpose of this study was to compare final correction angle between groups, as well as the absolute deviation from intended correction to achieved correction, a novel method to assess surgical accuracy in this procedure. Results demonstrated no Read More »
Level 2 RCT
Synopsis: 77 patients with symptomatic, Kellgren-Lawrence grade II-IV knee osteoarthritis were randomized to intraarticular hyaluronic acid (IAHA) injections with or without an additional, single periarticular lidocaine-corticosteroid injection (PALCI) at the beginning of treatment. The purpose of this study was to determine if the addition of PALCI to IAHA had a significant effect on pain after 1, 3, 6, 12, 26 and 52 weeks. Visual analog pain Read More »
Level 2 RCT
Synopsis: 26 patients scheduled for opening-wedge high tibial osteotomy were randomized to grafting with a dehydrated equine wedge with or without augmentation with a nanohydroxyapatite paste. The purpose of this study was to assess and compare graft integration between groups on CT over a 12-month follow-up. Results suggested better Read More »
Level 2 RCT
Synopsis: 222 patients with OARSI grades 1-3 knee osteoarthritis were randomized to intra-articular viscosupplementation with either an intermediate-molecular-weight hyaluronic acid plus mannitol, an antioxidant, (HAnOX-M), or high-molecular-weight hyaluronic acid (Bio-HA). The purpose of this study was to evaluate if the HAnOX-M group demonstrated non-inferior results on Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Function sub-scores compared to the Bio-HA group over 26-week follow-up. Results suggested non-inferiority Read More »
Author verified Level 2 RCT
Synopsis: 474 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were included in a 3-year, double-blind, RCT to evaluate the effect of vitamin D supplementation on the rate of radiographic disease progression. Compared to a placebo group, patients treated with vitamin D supplementation did not demonstrate a slower rate of joint space narrowing (JSN) on radiographs over the 3-year follow-up. There were also Read More »
Level 2 RCT
Synopsis: 192 patients with symptomatic, unilateral degenerative knee pathology were randomized to intraarticular injections of either leukocyte-rich platelet-rich plasma or high-molecular-weight hyaluronic acid. Injections were administered once weekly for 3 weeks. Outcomes reported included Read More »
Conference Report
Synopsis: 7 randomized controlled trials (RCTs) were included in this systematic review and meta-analysis comparing conservative treatment methods of intra-articular hyaluronic acid injections and corticosteroid injections. Pain scores were pooled at 2, 4, 8, 12, and 26 weeks post-injection. At early follow-up Read More »
Level 1 Meta Analysis
Synopsis: 63 randomised placebo-controlled trials were included in this meta-analysis to determine the maximal short-term effect of common pharmacotherapeutic interventions for short-term pain relief for knee osteoarthritis. Opioid therapy, oral NSAID, topical NSAID, steroid injections, paracetamol, glucosamine sulphate, and chondroitin sulphate were evaluated in this study. When assessed in Read More »
Level 2 Meta Analysis
Synopsis: Ten randomized controlled trials were included in this meta-analysis to evaluate the efficacy of intra-articular corticosteroid injections compared to placebo for the management of knee osteoarthritis. A dichotomous outcome of symptom improvement, defined as the most important patient-oriented outcome, and pain outcome were evaluated. Corticosteroid injections resulted Read More »
Level 2 Meta Analysis
Synopsis: Five randomized controlled trials were included in this meta-analysis to evaluate the efficacy of intra-articular corticosteroid injections compared to placebo in patients with knee osteoarthritis. The outcomes of interest that were pooled using meta-analysis were a failure to reach a target pain outcome and pain scores on a visual analog scale (VAS). Significantly fewer patients Read More »
Level 2 Meta Analysis
Synopsis: 29 out of 40 patients with osteoarthritis of the knee exhibited impaired conditioned pain modulation (CPM) and were randomized to one of two interventions (with cross-over thereafter) for the purpose of examining physiotherapeutic effects on knee pain, pressure pain thresholds, and vibration perception thresholds: (1) oscillatory joint mobilization or (2) cutaneous input (control -light placement of both hands on the subject's knee). Results demonstrated that Read More »
Author verified Level 2 RCT
Synopsis: 147 patients with advanced osteoarthritis of the knee or hip who were eligible for total knee arthroplasty (TKA) or total hip arthroplasty (THA) were randomized to receive two modes of patient decision-making tools for the purpose of comparing differences in patient knowledge, decision-making participation, satisfaction, and treatment preferences: (1) Educational DVD and booklet, or (2) Educational booklet only. When assessed at four weeks, both groups resulted in satisfactory improvements in various decision-aid related outcomes, such as patient knowledge score, confidence in decision making, and satisfaction with the intervention, however, the decision aids did not affect the willingness to participate in OA management. There were no Read More »
Level 2 RCT