Oral acetaminophen demonstrates similar analgesic efficacy to IV acetaminophen in TKA and THA

Am J Health Syst Pharm. 2018 Mar 15;75(6):367-375

AAOS 2016: IV + oral acetaminophen comparable for pain and narcotic use following TJA

Perioperative ibuprofen & acetaminophen vs. ibuprofen alone for analgesia in arthroplasty

Pain Physician. 2016 Jul;19(6):349-56

Neither additional IV nor oral acetaminophen enhances multimodal analgesia efficacy in TKA

J Arthroplasty. 2017 Oct;32(10):3029-3033

IV Titrated Morphine vs Hydrocodone/Acetaminophen for pain relief of lower extremity fractures in ED

Exp Ther Med. 2018 Oct;16(4):3674-3679.

Lower pain and need for opioids with IV acetaminophen vs. placebo after total hip arthroplasty

J Arthroplasty. 2019 Jun;34(6):1155-1161. doi: 10.1016/j.arth.2019.02.033

Diclofenac versus acetaminophen versus placebo for treatment of symptomatic knee osteoarthritis

Arch Intern Med. 2003 Jan 27;163(2):169-78

Preemptive/preventive acetaminophen reduces pain in lower extremity surgery

J Clin Anesth. 2013 May;25(3):188-92. doi: 10.1016/j.jclinane.2012.09.004. Epub 2013 Apr 6

Similar Pain Control With Oral and IV Acetaminophen in Elderly Trauma Patients With Rib Fracture

Am Surg. 2020 01-Aug;():. 10.1177/0003134820940268

TKA: Dual-opioid treatment reduces pain and adverse GI events vs. oxycodone/acetaminophen

Clin Ther. 2013 Apr;35(4):498-511. doi: 10.1016/j.clinthera.2013.03.002

AAOS2018: Ibuprofen/acetaminophen equal to hydrocodone/acetaminophen for post-hand surgery analgesia

Acetaminophen is a suitable treatment for moderate osteoarthritis pain of the knee

Osteoarthritis Cartilage. 2009 Jan;17(1):1-7. Epub 2008 Jul 21

NSAIDs versus acetaminophen for treatment of knee and hip osteoarthritis

Osteoarthritis Cartilage. 2011 Aug;19(8):921-9

ISAKOS 2015: Platelet-Rich Plasma favourable compared to acetaminophen for primary knee OA

Immediate- vs extended-release tramadol HCL/acetaminophen for pain following TKA

Curr Med Res Opin. 2015 Jan;31(1):75-84.

Epidural ropivacaine vs. IV PCA for postoperative pain after lumbar interbody fusion

Eur Spine J. 2016 May;25(5):1601-7.

Efficacy of acetaminophen - with and without tramadol - for analgesia in extremity fracture fixation

J Bone Joint Surg Am. 2017 Nov 15;99(22):1908-1915

AAOS 2016: Similar rates of nonunion with acetaminophen/NSAIDs in humeral shaft fractures

Oxycodone/Acetaminophen vs. Acetaminophen Alone for Musculoskeletal Pain Refractory to Ibuprofen

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2021 21-Aug;():. 10.1111/acem.14231.

OTA 2022: Multimodal Pain Protocol vs Hydrocodone-Acetaminophen