It is hard to imagine that the COVID-19 pandemic has been with us and impacted almost every aspect of our lives for the last 2 years. Everyone feels exhausted from this crisis and keeps asking when this pandemic will be over. Unfortunately, nobody can provide an exact answer. It is critical that we remain calm and continue to use evidence to guide our decisions. In this OE Original, we try to provide some answers to key questions about the SARS-CoV-2 Omicron variant of concern (VOC) (B.1.1.529). The Omicron variant has rapidly become the dominant SARS-CoV-2 strain on a global scale and outpaced the Delta variant in most countries. According to the World Health Organization (WHO), as of February 1, 2022, the Omicron VOC accounted for over.....