Fractures of the humerus, a common injury presenting to orthopedic surgeons, account for 1% to 3% of all fractures in elderly patients and 4% to 6% in young patients (Attum et al., 2021). The choice of open reduction and internal fixation of a humeral fracture with a plate versus an intramedullary nail is highly debated. Each treatment option has respective advantages. For instance, fixation using a plate allows direct visualization of the fracture site and facilitates the identification and protection of the radial nerve, whereas using intramedullary nail to fix humeral fracture preserves the periosteal blood supply and minimizes the disruption of the biology of the fracture healing (Zhao et al., 2015). The aim of the present OE Original was to determine whether the location of humeral fracture (i.e., proximal humeral fractures, humeral shaft fractures, and distal humeral fractures) needs to be taken into consideration when choosing between intramedullary nail- and...