Hyaluronon injection shows no benefit over placebo for treatment of knee osteoarthritis
Hyaluronon injection shows no benefit over placebo for treatment of knee osteoarthritis
Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy
Ann Rheum Dis. 1994 Aug;53(8):529-34Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
91 patients with knee osteoarthritis were randomized to receive either 5 weekly intra-articular injections of hyaluronan, or to receive 5 placebo intra-articular injections. The purpose of the study was to determine the clinical effects of hyaluronan injection therapy, in terms of its efficacy and safety. Outcomes included VAS pain scores, knee tenderness, and range of motion assessed up to 5 week...
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