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Immediate- vs extended-release tramadol HCL/acetaminophen for pain following TKA
March 2015
Immediate- vs extended-release tramadol HCL/acetaminophen for pain following TKA
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement
Curr Med Res Opin. 2015 Jan;31(1):75-84.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
320 patients who underwent total knee arthroplasty were randomized to either receive extended-release tramadol HCl 75 mg/acetaminophen 650 mg (TA-ER) or immediate-release tramadol HCl 37.5 mg/acetaminophen 325 mg (TA-IR) for a period of 48 hours after the discontinuation of patient-controlled analgesia (PCA) postoperatively. This was done to compare the efficacy and safety of the two treatments fo...
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