AAOS2017: NSAID does not impair pediatric long bone fracture healing

Study Type: Randomized Trial
OE Level of Evidence: N/A
Journal Level of Evidence: N/A
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Synopsis
81 pediatric patients with a long bone fracture were randomized to analgesia with either NSAID (ibuprofen) or acetaminophen. Patients were assessed over 6-month follow-up for fracture healing rate, time to fracture healing, and pain scores. Results demonstrated no Please login to view the rest of this report. Please login to view the rest of this report.
Why was this study needed now?
Various analgesic drugs are used for pain management following fracture. Specifically in children and adolescents, despite the common use of non-steroidal anti-inflammatory drugs (NSAIDs), no previous high-quality studies have examined the safety of theses agents related to fracture healing.
What was the principal research question?
In analgesia post-long bone fracture in pediatric patients, is there any significant difference in fracture healing between ibuprofen (NSAID) and acetaminophen?
Population: 81 patients, 16 years of age or younger, with a fracture of a long bone. All patients were given oxycodone for the management of breakthrough pain.
Intervention: Ibuprofen group: Patients were administered ibuprofen as part of their post-fracture analgesia regimen.
Comparison: Acetaminophen (control) group: Patients were administered acetaminophen as part of their post-fracture analgesia regimen.
Outcomes: Outcome measures included fracture healing, and pain on a visual analog scale (VAS),
Methods: RCT
Time: Follow-up intervals included 1-3 days, 1-2 weeks, 6 weeks, 10-12 weeks, and 6 months after injury.
What were the important findings?
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What should I remember most?
How will this affect the care of my patients?
The authors responsible for this critical appraisal and ACE Report indicate no potential conflicts of interest relating to the content in the original publication.