Related ACE Reports
- Published: Nov 1980
- ACE Report #9361
Injection of triamcinolone versus saline in patients with knee osteoarthritis
Study Type: Therapy
OE Level of Evidence: 2
Journal Level of Evidence: N/A
|Sponsor:||Arthritis and Rheumatism Council|
Why was this study needed now?
At the time this study was conducted there were few high-quality trials that had evaluated the efficacy of corticosteroid injections in the management of patient with knee osteoarthritis in comparison to a placebo injection.
What was the principal research question?
Does an intra-articular injection with triamcinolone hexacetonide reduce pain, function, and stiffness when compared to a placebo injection in patients with knee osteoarthritis?
|Population:||16 patients with unilateral or biliateral symptomatic knee osteoarthritis (n=24 knees) (Mean age: 65.0+/-8.1). A non-crossover RCT was also reported on in the publication, but only the results of the crossover RCT will be reported on in this ACE Report.|
|Intervention:||CS group: Patients were administered an injection of 1mL 20mg triamcinolone hexacetonide for the first injection. One week later, patients were administered an injection of 1mL saline. (n=12 knees).|
|Comparison:||Saline group: Patients were administered an injection of 1mL saline for the first injection. One week later, patients were administered an injection of 1mL 20mg triamcinolone hexacetonide(n=12 knees)|
|Outcomes:||Outcome measures included pain on a visual analog scale, duration of knee stiffness in the morning, joint tenderness on a 4 point scale, and patient opinion and preference between knees.|
|Time:||Patients were assessed at baseline prior to injection, 1 week after the first injection, and 1 week after the second injection.|
What were the important findings?
What should I remember most?
How will this affect the care of my patients?
The authors responsible for this critical appraisal and ACE Report indicate no potential conflicts of interest relating to the content in the original publication.