Greater patient preference for triamcinolone hexacetonide vs. saline injection in knee OA

Study Type: Therapy
OE Level of Evidence: 2
Journal Level of Evidence: N/A
12 patients with bilateral knee osteoarthritis had one knee randomized to injection with 20mg triamcinolone hexacetonide, and the other knee randomized to injection with saline. The purpose of this study was to compare pain, knee stiffness & tenderness, patient preference, and thermographic indices between knees over a 6-week follow-up. While reporting of Please login to view the rest of this report. Please login to view the rest of this report.
Funding: Non-Industry funded
Sponsor: Arthritis and Rheumatism Council
Conflicts: None disclosed
Why was this study needed now?
At the time this study was conducted there were few high-quality trials that had evaluated the efficacy of corticosteroid injections in the management of patient with knee osteoarthritis in comparison to a placebo injection.
What was the principal research question?
Is there a difference in patient preference between intra-articular injections of triamcinolone hexacetonide and placebo in patients with knee osteoarthritis?
Population: 12 patients with bilateral knee osteoarthritis. Randomization was performed between knees in included patients (Mean age: 63.5+/-8.2). A subsequent crossover study was also reported in the publication, but for the purposes of this reported, only the non-crossover RCT will be featured.
Intervention: CS group: In one knee, an injection of 1mL 20mg triamcinolone hexacetonide was administered. (n=12 knees)
Comparison: Saline group: In one knee, an injection of 1mL saline was administered. (n=12 knees)
Outcomes: Outcome measures included pain on a visual analog scale, duration of knee stiffness in the morning, joint tenderness on a 4 point scale, patient opinion and preference between knees, and thermographic index of the knees.
Methods: RCT
Time: Follow-up scheduled at 1, 2, 4, and 6 weeks post-injection
What were the important findings?
What should I remember most?
How will this affect the care of my patients?
The authors responsible for this critical appraisal and ACE Report indicate no potential conflicts of interest relating to the content in the original publication.