Immediate effects on bone metabolism biomarkers noted with resistance training and walking

Study Type: Therapy
OE Level of Evidence: 2
Journal Level of Evidence: N/A
Synopsis
150 women with osteoporosis or osteopenia were randomized to one of three groups; one group underwent a single session of resistance exercises, one group underwent a single session of simply walking, and one group was a control with no intervention. The purpose of this study was to examine and compare pre- and post-intervention serum levels of bone-specific alkaline phosphatase (BALP), C-terminal cross-linked telopeptide of type I collagen (CTX) and sclerostin between groups. No group demonstrated Please login to view the rest of this report. Please login to view the rest of this report.
Funding: Non-Industry funded
Sponsor: Faculty of Health Sciences, University of Pecs
Conflicts: None disclosed
CONTENT IS LOCKED
Why was this study needed now?
Analysis of bone metabolism through serum markers, such as bone-specific alkaline phosphatase (BALP), C-terminal cross-linked telopeptide of type I collagen (CTX), has been recently popular in the evaluating various treatment efficacies for patients at high risk of fracture, such as those with osteopenia or osteoporosis. Weight-bearing and resistance exercises are thought to play a crucial role in the regulation and changes of these markers for overall improvement of bone metabolism and health. Nonetheless, very few randomized controlled trials have been performed evaluating these effects.
What was the principal research question?
In women with osteoporosis or osteopenia, what immediate effect does a single session of either resistance training or walking have on bone metabolism biomarkers, compared to no intervention?
Population: 150 women with osteoporosis or osteopenia.
Intervention: Resistance training group: First, participants took part in an 8-min warm-up targeting major muscle groups. This was followed by 30-min of various muscle strengthening and core stabilizing exercises (see publication for full program). Lastly, an 8-min cool-down consisted of walking and stretching exercises. (n=50; Mean age: 60.2+/-6.9) Walking group: Participants walked for 46-min on even ground at a rate of 100 steps/min. Rhythm was aided by a metronome. (n=50; Mean age: 58.7+/-6.3)
Comparison: Control group: Participants did not receive any intervention. (n=50; Mean age: 57.8+/-8.4)
Outcomes: Serum concentrations of bone-specific alkaline phosphatase (BALP), C-terminal cross-linked telopeptide of type I collagen (CTX), and sclerostin were measured.
Methods: RCT
Time: Blood samples were collected within 5 minutes of completing allocated intervention.
What were the important findings?
What should I remember most?
How will this affect the care of my patients?
The authors responsible for this critical appraisal and ACE Report indicate no potential conflicts of interest relating to the content in the original publication.