Showing 1 - 11 of 11 reports matching: Perioperative_Interventions_for_Cardiac_Events
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Synopsis: 9298 patients with, or at risk of, atherosclerotic disease and undergoing non-cardiac surgery, were randomized to receive perioperative administration of either extended-release metoprolol or a placebo equivalent. The purpose of this study was to compare these two groups with respect to rates of cardiovascular complications over a period of 30 postoperative days. Results indicated that, Read More »
Level 1 RCT
Synopsis: 10,010 patients with, or at risk for, major vascular disease, and undergoing non-cardiac surgery were randomized to receive either aspirin or placebo (both with and without clonidine) as part of the Perioperative Ischemic Evaluation 2 (POISE-2) trial. This report, Part 1, summarizes the data pertaining to the safety and efficacy of aspirin, while clonidine-related data is summarized in Part 2. Results over 30 Read More »
Level 1 RCT
Synopsis: 10,010 patients with, or at risk for, major vascular disease, and undergoing non-cardiac surgery were randomized to receive either clonidine or placebo (both with and without aspirin) as part of the Perioperative Ischemic Evaluation 2 (POISE-2) trial. This report, Part 2, summarizes the data pertaining to the safety and efficacy of clonidine, while aspirin-related data is summarized in Part 1. Results over 30 Read More »
Level 1 RCT
Synopsis: 15,133 patients (45 years or older) undergoing non-cardiac surgery were included in this study (the VISION fourth-generation TnT prognostic study). The purpose of this large, international prospective cohort study was to determine whether peak postoperative troponin-T (TnT) values are associated with 30-day mortality rates. Results indicated that Read More »
Level 2 RCT
Synopsis: 187 patients (>60 years) undergoing emergency (i.e. non-elective) surgery in an orthopaedic unit were included. Patients who demonstrated a postoperative increase in troponin (n=70) were randomized to undergo either 24 hours of cardiology care or standard care, within 24 hours of troponin measurement to compare these two interventions with respect to mortality rates at 1 year. Results indicated that, Read More »
Level 2 RCT
Synopsis: 921 patients (>39 years) with either insulin- or non-insulin-dependent diabetes, scheduled to undergo major orthopaedic surgery were randomized to receive perioperative beta blockade (metoprolol) or a placebo. The primary purpose of this study was to determine whether the perioperative administration of metoprolol significantly improved the incidence of the following composite outcome: all-cause mortality, acute myocardial infarction, unstable angina, or congestive heart failure during hospital admission. Results indicated that Read More »
Level 1 RCT
Synopsis: 187 patients (>60 years old) undergoing emergency orthopaedic surgery and participating in a randomized controlled trial were monitored in this observational study. The purpose of this analysis was to determine whether both pre- and postoperative levels of the inactive form of brain natriuretic peptide (N-terminal pro-BNP) and angiotensin-converting enzyme 2 (ACE-2) significantly predict the incidence of cardiac events in hospital and at 1 year. Results indicated that Read More »
Level 2 RCT
Synopsis: 7925 patients from the POISE trial were included in this post-hoc analysis regarding neuraxial block. The purpose of this analysis was to determine whether neuraxial block was significantly associated with the primary composite outcome (i.e., cardiovascular death, non-fatal myocardial infarction, or non-fatal cardiac arrest), myocardial infarction, stroke, and clinically-significant hypotension over 30 days post-operation. Results indicated that Read More »
Author verified RCT
Synopsis: 220 high-risk patients undergoing elective, high- or intermediate-risk non-cardiac surgery were randomized to receive either aspirin (75 mg) or placebo daily, beginning 7 days prior to surgery until the third postoperative day. The purpose of this study was to determine whether continuing aspirin therapy in the perioperative period significantly reduced myocardial damage and the incidence of major cardiac adverse events (MACEs), without affecting bleeding outcomes, over 30 days post-operation. Results indicated that, Read More »
Author verified Level 1 RCT
Synopsis: 40 patients with, or at risk for, coronary artery disease and undergoing non-cardiac surgery were randomized to receive either a xenon-opioid anaesthetic or propofol-opioid anaesthetic. The purpose of this study was to compare these two interventions with respect to the preservation of left ventricular function, as well as intraoperative mean arterial pressure. Results indicated that Read More »
Author verified Level 2 RCT
Synopsis: Sixty patients with hip fractures were randomized to undergo surgical treatment using either an accelerated or the standard treatment protocol, in order to assess the feasibility of a true randomized controlled trial comparing these two approaches. Overall, feasibility targets were attained, with 60 patients recruited in less than 18 months, over 70% of eligible patients undergoing randomization, and 100% rate of 30-day follow-up. Major perioperative complications Read More »
Author verified Level 2 RCT