AAOS2017: Similar efficacy between IA TXA and IV TXA in total knee arthroplasty

Study Type: Randomized Trial
OE Level of Evidence: N/A
Journal Level of Evidence: N/A
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110 patients scheduled for total knee arthroplasty were randomized to be administered either intraarticular tranexamic acid or intravenous tranexamic acid. Patients were assessed for perioperative blood loss based on the drop in hemoglobin to the third postoperative day. Transfusion requirement and Please login to view the rest of this report. Please login to view the rest of this report.
Why was this study needed now?
Many studies have been completed investigating the efficacy of tranexamic acid in total joint arthroplasty. More recently, there has been an emergence of randomized controlled trials comparing the efficacy of different routes of administration of tranexamic acid. This study sought to compare the efficacy of intraarticular and intravenous tranexamic acid in total knee arthroplasty.
What was the principal research question?
In total knee arthroplasty, is there any significant difference between intravenous administration and intraarticular administration of tranexamic acid in terms of blood loss and complications?
Population: 110 patients scheduled for total knee arthroplasty without postoperative drainage.
Intervention: IA TXA: Patients were administered intravenous tranexamic acid. (n=55)
Comparison: IV TXA: Patients were administered intraarticular tranexamic acid. (n=55)
Outcomes: Perioperative blood loss was calculated from the drop in hemoglobin between preoperative levels and postoperative day 3. Transfusion rate and incidence of venous thromboembolic complications were recorded.
Methods: RCT
Time: Perioperatively.
What were the important findings?
What should I remember most?
How will this affect the care of my patients?
The authors responsible for this critical appraisal and ACE Report indicate no potential conflicts of interest relating to the content in the original publication.