Related ACE Reports
- Published: Mar 2017
- ACE Report #9568
AAOS2017: Similar efficacy between IA TXA and IV TXA in total knee arthroplasty
Study Type: Randomized Trial
OE Level of Evidence: N/A
Journal Level of Evidence: N/A
CONFERENCE ACE REPORTS
This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.
Why was this study needed now?
Many studies have been completed investigating the efficacy of tranexamic acid in total joint arthroplasty. More recently, there has been an emergence of randomized controlled trials comparing the efficacy of different routes of administration of tranexamic acid. This study sought to compare the efficacy of intraarticular and intravenous tranexamic acid in total knee arthroplasty.
What was the principal research question?
In total knee arthroplasty, is there any significant difference between intravenous administration and intraarticular administration of tranexamic acid in terms of blood loss and complications?
|Population:||110 patients scheduled for total knee arthroplasty without postoperative drainage.|
|Intervention:||IA TXA: Patients were administered intravenous tranexamic acid. (n=55)|
|Comparison:||IV TXA: Patients were administered intraarticular tranexamic acid. (n=55)|
|Outcomes:||Perioperative blood loss was calculated from the drop in hemoglobin between preoperative levels and postoperative day 3. Transfusion rate and incidence of venous thromboembolic complications were recorded.|
What were the important findings?
What should I remember most?
How will this affect the care of my patients?
The authors responsible for this critical appraisal and ACE Report indicate no potential conflicts of interest relating to the content in the original publication.