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Glucosamine and chondroitin combined therapy and monotherapy vs celecoxib and placebo for knee OA
September 2017
Glucosamine and chondroitin combined therapy and monotherapy vs celecoxib and placebo for knee OA
Study Type:Therapy
OE Level Evidence:N/A
Journal Level of Evidence:N/A
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
N Engl J Med. 2006 Feb 23;354(8):795-808Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
1583 patients with symptomatic knee osteoarthritis were randomized to either glucosamine monotherapy, chondroitin monotherapy, combined glucosamine and chondroitin therapy, celecoxib 200mg daily, or placebo. Patients were assessed over 24 weeks of treatment. In the primary analysis, only the celecoxib group demonstrated a significantly higher rate of patients attaining the primary efficacy endpoin...
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