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Zoledronic acid reduces rates of new clinical fractures after hip fracture repair

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Ace Report Cover
August 2013

Zoledronic acid reduces rates of new clinical fractures after hip fracture repair

Vol: 2| Issue: 7| Number:166| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Zoledronic Acid and Clinical Fractures and Mortality after Hip Fracture

N Engl J Med. 2007 Nov 1;357(18):1799-809. Epub 2007 Sep 17

Contributing Authors:
KW Lyles CS Colón-Emeric JS Magaziner JD Adachi CF Pieper C Mautalen L Hyldstrup C Recknor L Nordsletten KA Moore C Lavecchia J Zhang P Mesenbrink PK Hodgson K Abrams JJ Orloff Z Horowitz EF Eriksen S Boonen HORIZON Recurrent Fracture

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Synopsis

2127 patients were randomized to one of two groups to examine the rates of new clinical fractures after hip fracture repair. The first group received an annual infusion of zoledronic acid (a potent bisphosphonate), while the second group received a placebo. Results indicated that an annual infusion of zoledronic acid is associated with reduced rates of new clinical fractures and subsequently, morb...

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