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Intraosseous administration of low-dose vanomycin leads to higher tissue concentrations
April 2014
Intraosseous administration of low-dose vanomycin leads to higher tissue concentrations
Study Type:Randomized Trial
OE Level Evidence:2
Journal Level of Evidence:1
Higher tissue concentrations of vancomycin with low-dose intraosseous regional versus systemic prophylaxis in TKA: a randomized trial
Clin Orthop Relat Res. 2014 Jan;472(1):57-65. doi: 10.1007/s11999-013-3038-zDid you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
32 patients scheduled for total knee arthroplasty were randomized to received three different prophylactic antibiotic regimens: intraosseous administration of either 250mg or 500mg vanomycin, or 1g vanomycin administered intravenously. The purpose was to evaluate the effect of intraosseously administered vanomycin in terms of concentrations in subcutaneous fat, cancellous bone, and systemic blood ...
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