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Antiresorptive effects of single zoledronate dose are sustained for 3 years
October 2014
Antiresorptive effects of single zoledronate dose are sustained for 3 years
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Prolonged antiresorptive activity of zoledronate: a randomized, controlled trial
J Bone Miner Res. 2010 Oct;25(10):2251-5Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
50 postmenopausal women with osteopenia were randomized to receive either a single 5 mg dose of intravenous zoledronate or a placebo to determine the duration of antiresorptive action. Patients were assessed for bone turnover markers b-C-terminal telopeptide of type I collagen (b-CTX) and serum procollagen type-I N-terminal propeptide (P1NP). They were also assessed for bone mineral density (BMD) ...
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